In this study effect of strain hardening on crack growth rate has been examined analytically on the side edge notched specimen of 5052 Aluminum alloy in mode I under constant amplitude loading using finite element method based software Abaqus ® 6.10 which very well accepted program in research. Extended Finite Element Method Module has been used to determine plastic strains and stresses at the crack tip while propagation takes place. Experiments have been done at R-0.1, 0.2, 0.3, 0.5 on constant amplitude fatigue loading. Analytical results have given good agreement with experimental results. Regression analysis has also been done with SPSS 16.0 to check the dependency of strain hardening coefficient on fatigue crack growth rate the results show the justified dependency.