Background: The motor axonal neuropathy form of Guillain-Barré Syndrome is a fulminant paralytic disease where sensory nerves are protected but characterized by motor nerve degeneration in variable severities. In most cases, there is a history of infection caused by Campylobacter jejuni, and many cases have antibodies directed toward GM1 ganglioside-like epitopes.\nFindings: In this article, a 46 year old woman presented with fulminant progressive muscle weakness, albuminocytologic disproportion in cerebrospinal fluid, positive antiganglioside antibodies, displaying findings consistent with acute motor axonal neuropathy in electrophysiological studies, and responding to intravenous immunoglobulin treatment, however maintaining hyperreflexes in the course of the disease. \nConclusions: This case is important for considering that deep tendon reflexes should not be affected and may even be hyperactive at early stages of diagnosis based on clinic findings.