In the face of global food security challenges, optimizing agricultural productivity has become a critical focus for scientists worldwide. This study explores the impact of integrated nutrient management (INM) on crop yield across different agro-ecological zones. The objective was to assess how balanced use of fertilizers combined with organic farming techniques can enhance crop performance and sustainability. Field experiments were conducted over two growing seasons in Lithuania, China, and Senegal. Various INM strategies involving chemical fertilizers, farm manure, and legume cover crops were evaluated. Our findings indicate a significant increase in yield and improvement in soil health parameters in regions employing INM practices compared to traditional methods. Furthermore, INM contributed to a decrease in synthetic fertilizer inputs by 30% without compromising crop quality. This research underscores the importance of adopting sustainable agricultural practices that can be tailored to specific ecological conditions. The conclusion advocates for policy reforms and farmer training programs to implement INM techniques effectively, fostering resilient agricultural systems and ensuring food security.