Cognitive Behavioral Therapy (CBT) is a widely endorsed psychotherapeutic approach for the treatment of anxiety disorders. Despite its efficacy, cultural contexts may influence treatment outcomes. This study aims to investigate the effectiveness of CBT across diverse cultural settings to better understand its universal applicability. Researchers conducted a comparative analysis involving clinical trials from three distinct regions, each representing unique cultural perspectives: South Asia, the Middle East, and Oceania. The sample comprised 300 participants diagnosed with generalized anxiety disorder, who underwent a structured CBT program over 12 weeks. Data were collected using standardized psychological assessments and self-reported measures. Findings indicated significant reductions in anxiety levels among participants across all cultural groups, though variations in response rates were noted. Cultural factors, such as belief systems and social support, appeared to moderate the efficacy of the intervention. The study concludes that while CBT is an effective treatment modality for anxiety disorders, integrating cultural considerations enhances therapeutic outcomes. Future research should further explore culturally adapted CBT protocols to optimize efficacy for diverse populations.