Abstract:\nAcute liver failure (ALF, sometimes referred to as fulminant hepatic failure) is a severe liver disease characterized by encephalopathy and coagulopathy in patients with previously normal liver function. It has a duration of less than 26 weeks and high mortality. The present study was investigated to evaluate the effects of Solanum surrattense on hepatic failure in female mices which experimentally infected byPlasmodium berghei,ANKA-strain. Female BALB/C mices (n=40) were allocated into four groups, group one received tachyzoites of P.berghei (ip) (n=10), group two received tachyzoites of P.berghei (ip) plus fresh Plant extract by gavage method (n=10), group three received just fresh Plant extract by gavage method (n=10) and control group (n=10) received nothing. Animals were kept in standard condition. In 14 day after inducing Plasmodium infection, 2CC blood were collected for serum GGT, GLDH, protein, albumin, malondialdehyde (MDA) and total antioxidant capacity (TAC) levels. Liver tissues of mice in whole groups were removed and prepared for analysis. Serum albumin and TAC were significantly decreased in group that was infected with P.berghei, in comparison to control and Plant extract groups. Liver weights in plasmodium group significantly decreased in comparison to control group (P<0.05). This study showed that P.berghei have significantly effect on serum GGT, albumin, glutamate Dehydrogenase (GLDH), MDA and TAC and fresh plant extract returned and treated this harmful effect, so it is suggested that eating of plant extracts is useful in plasmodium infection.