In present study the organophosphate was administered orally at the dose of 15mg/kg of body weight to Swiss albino mice for 45 days to observe the effect on kidney of mice. The mice were then administered orally with Azolla filiculoides at the dose of 10 mg/kg of body weight for 30 days. The kidney function test (KFT), lipid peroxidation and histopathology of Kidney tissue were evaluated in respective treated groups. The study reveals that profenofos causes deleterious effect on biochemical parameters, as there was immense increase in the kidney function test levels. The histopathological observations also revealed high degree of degeneration in renal cells. But, after Azolla filiculoides administration for 30 days there was amelioration in the kidney function test levels as well as restoration in the nephrocytes reveals nephro-protective effect. The findings suggest that the Azolla filiculoides is the suitable antidote against arsenic induced toxicity and possesses nephroprotective activity.