This study was carried out to investigate the effects on growth performance, feed evaluation and bio-economic analysis of tilapia, Tilapia zillii when replacing wheat meal with olive pomace meal at 10%. 20% and 30% ratios. The initial average weight of tilapia was 3.95±0.02 g. The trial was performed among four groups and three replications of 10 fishes/ aquarium fed with experimental diets for 45 days. During the first week fish were fed five times a day with 8% of their body weight and 6% during the second, third and other weeks for 45 days. To determine the growth performance and feed evaluation fish were weighed every 15 days with water temperature being measured every day. The relative growth rate (RGR %) in the control group was 36.38±17.6% 10% in olive pomace meal group 25.22±3.51% 20% in olive pomace meal group 34.08±0.83% and 30% in olive pomace meal group 28.91±6.15% (p>0.05). The best feed conversion ratio was observed in the control group the other groups increased in line with increase of olive pomace meal in diets (p>0. 05). Specific growth rate (SGR) was found to be 0.68±0.29 in control group, 10% in group 0.50±0.11, 20% in group 0.65±0.01 and 30% in group 0.56±0.11 (p>0.05). The use of 20% olive pomace meal diet showed similarities with control group growth performance and specific growth rate results. The use of 10 % olive pomace meal in diets showed similarities with control group on feed conversion ratio. The research did not show any statically significant on the growth parameter among the fish groups that were fed with or without the olive pomace (p>0.05). On the other hand, the feeding costs of the olive pomace groups were found higher than the control fish group. In conclusion, specific proportions of olive pomace meal may be used as an alternative raw source in Tilapia zillii juvenile diets.