To evaluate and compare three types of sprayers, in terms of effects on biological yield, thousand seeds weight, and weed control of wild sesame, an experiment with five treatments and three replications was carried out. Treatments consisted of tractor boom sprayer, micronair (vaporizer), atomizer, hand weeding, and weeding-free control. The means were compared through Duncan method with MSTATC and the results of variance analyses, thousand seeds weight, biological yield, number, wet and dry weight of weeds showed a significant difference at the 1% level between atomizer and micronair and tractor boom sprayers.