Drought stress in the most stages of crops growth in arid and semiarid regions causes growth restriction and failure to achieve optimal performance. In the field research, in order to evaluate the effect of irrigation-cutback which was achieved because of lack of water in the study area and spraying the CYTOKININ hormone (CK) at different stages of crop growth on performance and components of HAMOON wheat performance, a test was conducted in 2013-2014, and design format was done as split plot in a randomized complete block with four replications. In this study, irrigation-cutback is done in two levels, irrigation in heading stage (Z59) to harvesting and irrigation-cutback at the flowering stage (Z69) to harvesting. The effect of irrigation-cutback treatments on plant height, peduncle height, seed yield and seed weight was significant at the 5% level. Effect of CYTOKININ spraying (CK), and full irrigation on grain yield and grain weight was significant. Irrigation-cutback at each stage was impressive, and full irrigation in all growth stages of wheat and spraying CK, simultaneously and without interrupting any of the two, increases grain yield significantly and grain weight in wheat in comparison other treatments. Therefore, the use of full irrigation at different growth stages of wheat and spraying CK, in later stages of the growth of HAMOON wheat to produce more in SISTAN region is good advice, if water is provided for farmers with timely or with low latency water is provided for agricultural fields, therefore acceptable performance with spraying CK is seen in their field.