The objective of the present study was to investigate the role of some heavy metals in Rheumatoid Arthritis (RA). The metal concentrations were observed in serum of RA patients. We also compared the heavy metal concentrations between sexes and two age groups i.e., below 35 years and 35 years and above. The metals studied were copper, zinc, cobalt, lead and nickel. The results indicated that concentration of Cu was significantly lower in the serum of RA+ve patients as compared to RA-ve individuals. However, there was no difference in Zn, Co, Pb, and Ni concentrations of RA patients and healthy persons. Concentrations of heavy metals were not found to be related with the age or sex of the RA patients.