Abstract \nThe aim of this clinical trial was to investigate the efficacy of florfenicol (FFC) in the treatment of caprine pasteurellosis (CP) at their different ages and sexes. Fourty Saanen caprine with pasteurelosis infection were used in this study. After diagnosed of RD by their clinical, necroscopic and microbilogic examinations, the caprines were randomly divided into two groups: The infected control (C) group (n=10) remained unmedicated with an antibiotic, whereas the other group animals (n=30) named florfenicol (FFC) treatment group were subcutaneously medicated with florfenicol (Nuflor®Intervet, Turkey) at the twice doses of 20 mg/kg body weight intramuscularly 48 hours intervals. All the animals were assessment clinically before treatment and on the 1st (inclusion day), 3th, 7th and 10th days of the therapy. The drug efficacy was assessed with regard to clinical, microbiological (animals showed severe clinical signs of illness) and necroscopical findings (severe ilness animal) at the exact dates. At the end of the first day of administiring FFC, body temperature and respiratory rates in naturally infected animals which were high had decreased significantly (p<0.05) lower than in the animals not received treatment . Over the period of the study after treatment, therapy with FFC produced significantly (p<0.05) greater symptomatic improvement and well tolerated considering their clinical scores.