People are always looking for secure methods to protect valuable information against unauthorized access\nor use. That’s why, disciplines like cryptography and steganography are gaining a great interest among\nresearchers. Although the origin of steganography goes back to the ancient Greeks, recent steagnographic\ntechniques hide data into digital media such as sound, images, and videos. However, steganography took a\nstep further to utilize the DNA as a carrier of secret information. DNA-based steganography techniques\ncould be used for either authentication or data storage. In this paper, we propose an original idea of hiding\ndata in DNA or RNA called LSBase (Least Significant Base Substitution). It uses a remarkable property of\ncodon redundancy to introduce silent mutations into DNA sequences. In this way, the DNA sequence can\nbe altered without affecting the type or the structure of protein it produces. When compared with other\ntechniques, the proposed algorithm showed to be the only blind technique that is capable of conserving the\nfunctionality of the carrier DNA while maintaining a reasonable data payload.