The antimicrobial potential of two ethnomedicinal plants, (Echinops spinosus and Limoniastrum monopetalum) extracted with different solvents (ethanol, ethyl acetate, hexane, chloroform and water) was investigated. The medicinal plants varying antimicrobial susceptibility patterns were exhibited. The ethyl acetate extracts plants showed antibacterial activity against all microorganisms used in this study. The microorganism (Kiebsiella pneumoniae pneumoniae) was susceptible to the ethyl acetate extracts plants with minimum inhibitory concentration values 2.5mg/mL for Echinops spinosus and 5.0 mg/mL for limoniastrum monopetalum while all microorganisms appeared to be resistant to the aqueous extracts plants used. The results suggested that these plants were potential sources of antimicrobial agents.