X-ray repair cross-complementing group 1 (XRCC1) is a DNA-repair gene which involved in base excision repair pathway, as a scaffolding protein. We investigated the association of XRCC1 Arg194Trp (rs1799782C>T) and Arg280His (rs25489 G>A) polymorphisms of in sporadic colorectal cancer (CRC) in a population from the north east of Iran. The study group consisted of 112 patients diagnosed with sporadic CRC, while the control group was composed of 110 race, sex and age-matched non-cancer volunteers. Genotyping was performed by T- ARMS-PCR. Overall results of this study, demonstrated that Arg194Trp and Arg280His have not significantly association to colorectal cancer risk. However, homozygote minor allele 194 Trp/Trp is further in colorectal cases than controls, OR is 2, but P value is >0.05, therefore has not statistically association with CRC risk. Heterozygote minor allele XRCC1 194 /Trp, although, OR is more than 1 but its p value is >0.05, hence, is not significantly relation with CRC risk. Totally, Arg194Trp is further in colorectal cases than controls, but statistically not significant. Only OR of 280His/His is more than 1 (2.860) but p value is >0.05. Other ORs of Arg280His are less than 1 and all p values are >0.05. Hence heterozygote Arg280His is further in controls than colorectal cases and has inverse association with CRC risk, however, because p values are >0.05, is statistically not significant. In Conclusion, Our findings suggest that SNP variants in XRCC1 possibly not play an important role in the development of CRC in an Iranian population.