MCM-41 mesoporous silica is synthesized based on a self assembly method, using a quaternary ammonium template, cetyl trimethyl ammonium bromide (CTAB) for the adsorption of sulfur compounds from model oil (1.0 mmol/l Dibenzothiophene in dodecane solution). Then the adsorption capability of MCM-41 assembled on the surface of bacterium Rhodococcus erythropolis IGTS8 is examined regarding the improvement of the biodesulfurization process of the oil compound based on the measurement of Dibenzothiophene (DBT) consumption rate and 2-HBP production. Study of the model oil desulfurization by the cells assembled with MCM-41 nanosorbent showed a further improvement in DBT reduction rate in comparison with the free cells. The results of the investigations showed that the maximum specific desulfurization activity in terms of DBT consumption rate and 2-HBP production are 0.34 µmol DBT min-1g DCW-1 and 0.126 µmol 2-HBP min-1g DCW-1 which indicated an increase of 19% and 16% compared to the highest specific desulfurization activity of free cells, respectively.