Pakistan is one of the most natural disaster-prone countries in the World. Natural disasters often result in great losses, in terms of both materials and people’s lives. During 2010 as large areas of the country lies under floodwaters, this caused huge devastation in Muzaffargarh District. Public infrastructure, agricultural land and homes were intensely affected by floodwater, many parts were unapproachable by road and some important bridges were collapsed. The aim of the present study explored an assessment of flood rehabilitation strategies in Muzaffargarh district. At the first stage two union councils i.e. Union Council No. 46 (Manka Bhutta) and Union Council No. 44 (Ghazanfargar) were selected randomly, at the second stage four villages two from each UC (Hassan Pur and Golay wala from UC- 46 and Mosa Wala and Jilal Wala Peer from UC-44) were selected randomly. Proportional sample size of 110 respondents was selected by simple random technique. Data were collected through well-structured interviewing schedule). Data were analyzed through Statistical Package for Social Sciences (SPSS). It was found the floods had negative impact on income and economic sources. Majority of the respondents reported that the damages during flood i.e. irrigation system (72.7%), housing (63.6%), agriculture (82.7%), livestock (74.5%), transport and communication (79.1%), education (77.3%), health (85.5%), water supply and sanitation (84.5%) and environment 87.3%)badly affected by flood. It was found many problems in flood affected areas i.e. safe drinking water, food, appropriate health facilities, availability of cloth, limited living space, privacy disturbance. Government and non-government organizations (NGOs) had major role in rehabilitation of flood affects in the selected area. Government and non-government organizations had their role in housing, shelter, food and the improvement of infrastructure in the flood affected areas.